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Tuesday, 28 August 2018
In a study conducted with over 2,000 overweight individuals with pre-diabetes who followed a low-calorie diet for 8 weeks, men lost significantly more body weight than women.
Men also had larger reductions in a metabolic syndrome score, a diabetes indicator, fat mass, and heart rate. Women saw larger reductions in HDL-cholesterol, hip circumference, lean body mass and pulse pressure than men
"Despite adjusting for the differences in weight loss, it appears that men benefitted more from the intervention than women. Whether differences between genders persist in the long-term and whether we will need to design different interventions depending on gender will be interesting to follow," said lead author Dr. Pia Christensen (University of Copenhagen in Denmark.) "However, the 8-week low-energy diet in individuals with pre-diabetes did result in the initial 10% weight loss needed to achieve major metabolic improvement in the first phase of a diabetes prevention programme."
Pia Christensen, Thomas Meinert Larsen, Margriet Westerterp-Plantenga, Ian Macdonald, J. Alfredo Martinez, Svetoslav Handjiev, Sally Poppitt, Sylvia Hansen, Christian Ritz, Arne Astrup, Laura Pastor-Sanz, Finn Sandø-Pedersen, Kirsi H. Pietiläinen, Jouko Sundvall, Mathijs Drummen, Moira A. Taylor, Santiago Navas-Carretero, Teodora Handjieva-Darlenska, Shannon Brodie, Marta P. Silvestre, Maija Huttunen-Lenz, Jennie Brand-Miller, Mikael Fogelholm, Anne Raben. Men and women respond differently to rapid weight loss: Metabolic outcomes of a multi-centre intervention study after a low-energy diet in 2500 overweight, individuals with pre-diabetes (PREVIEW). Diabetes, Obesity and Metabolism, 2018; DOI: 10.1111/dom.13466