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Monday, 06 January 2014
Use for 2 or more years of proton pump inhibitors and histamine 2 receptor antagonists (two types of acid-inhibiting medications) was associated with a subsequent new diagnosis of vitamin B12 deficiency, according to a new study.
"Vitamin B12 deficiency is relatively common, especially among older adults; it has potentially serious medical complications if undiagnosed. Left untreated, vitamin B12 deficiency can lead to dementia, neurologic damage, anaemia, and other complications, which may be irreversible," according to background information in the article. Proton pump inhibitors (PPIs) and histamine 2 receptor antagonists (H2RAs) suppress the production of gastric acid, which may lead to malabsorption of vitamin B12, and they are among the most commonly used medications.
Douglas A. Corley, MD, PhD, of the Kaiser Permanente Division of Research along with colleagues conducted a study of 25,956 patients who had a vitamin B12 deficiency. Their findings showed that 12 percent of patients who used protein pump inhibitors for two years had a significant deficiency of vitamin B12.
"Patients who took PPI medications for more than two years had a 65 percent increase in their risk of B12 deficiency. Higher doses also were associated with an increased risk, compared with lower doses. " according to Dr. Corley.
SOURCE: Journal of the American Medical Association, December 2013