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Why you need it?
Lysine is one of the essential amino acids. It is found highest in muscles with only glutamic acid and aspartic acid being higher. Lysine is degraded to acetyl CoA, a critical intermediate in the Kreb cycle. Enzymes involved with acetyl CoA have been found in decreasing order in the liver, kidneys, heart, adrenal glands, thymus gland, brain and skin. Lysine is the precursor to carnitine and citrulline. Minor amounts of lysine can be made into pipecolic acid, a neurotransmitter in the brain, and it works with the help of niacin. Arginine and ornithine are antagonistic to lysine and if given in large amounts can lead to a deficiency of lysine. Lysine is metabolized with the help of vitamins B-2 and B-3.
Deficiency symptoms usually show a decreased immune function as well as decreased growth. Certain vegetarian foods can be found to be deficient in lysine. Refined grains, corn, sunflower seeds, peanuts, and vegetables are generally low in lysine. In vegetarian diets legumes are used to supply the needed lysine. There may also be a connection with lysine deficiency and kidney stones (calcium oxalate).
Good Food Sources:
Wheat germ, meat, eggs, fish, poultry, cheese, lima beans, shrimp, mung bean sprouts, cottage cheese, yeast.
Beneficial For :
- Essential amino acid- necessary building block for all proteins.
- High serum triglyceride levels
- Helps fight cold sores & mouth ulcers
GRAS - Generally recognized as safe. No adverse reactions, side effects or overdose symptoms expected when taken within the recommended amounts.
In mice and chicks high intakes of lysine can cause increased cholesterol levels. In humans lysine has very little toxicity, even at high doses. Doses up to 8 g q.d. seem to be innocuous.
1.9 gm/kg IV given to rats (140 g in man equivalent dose) increase kidney toxicity to aminoglycoside antibiotics. In the absence of antibiotics no toxic effects have been noted.
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